Isotroin

Prescription Oral Retinoid

Isotretinoin Capsules

Manufacturer: Cipla

Description

Isotroin is Cipla's branded oral isotretinoin (13-cis-retinoic acid) — the most effective treatment for severe, nodulocystic, and recalcitrant acne. It reduces sebum production by up to 90%, normalises keratinisation, and has anti-inflammatory and anti-bacterial effects. The only acne drug that can induce long-term remission.

Active Compounds

Isotretinoin

Active ingredient — oral retinoid

Concentration: 10mg / 20mg / 40mg

Tretinoin is a first-generation retinoid derived from vitamin A. It is one of the most extensively s…

Indications

  • Severe nodulocystic acne
  • Recalcitrant acne unresponsive to conventional therapy
  • Acne with scarring tendency

Dosage

0.5–1 mg/kg/day for 16–24 weeks. Cumulative dose target: 120–150 mg/kg. Take with fatty food for absorption.

Formulations

Soft gelatin capsule

Full Ingredient List

  • Isotretinoin
  • Soybean Oil
  • Beeswax
  • Butylated Hydroxyanisole
  • Edetate Disodium
  • Gelatin Capsule Shell

Side Effects

  • Severe dryness (lips, skin, eyes)
  • Elevated liver enzymes and triglycerides
  • Musculoskeletal pain
  • Mood changes (monitor carefully)
  • Photosensitivity
  • Initial acne flare

Warnings

  • Pregnancy Category X — ABSOLUTE contraindication (teratogenic)
  • Mandatory pregnancy test before and during treatment
  • Monthly blood tests (CBC, LFT, lipid panel) required
  • Avoid blood donation during and 1 month after treatment
  • Avoid vitamin A supplements
  • Avoid waxing and laser procedures during treatment

Related Conditions

Acne Vulgaris Oral isotretinoin for severe and recalcitrant acne