Differin

OTC / Prescription Topical Retinoid

Adapalene Gel

Manufacturer: Galderma

Description

Differin is a third-generation retinoid available over-the-counter at 0.1% strength. It offers comparable efficacy to tretinoin with significantly better tolerability and photostability.

Active Compounds

Adapalene

Active ingredient

Concentration: 0.1% (OTC) / 0.3% (Rx)

Adapalene is a third-generation synthetic retinoid that selectively binds to RARβ and RARγ receptors…

Indications

  • Acne vulgaris
  • Maintenance therapy for acne

Dosage

Apply a thin layer to affected areas once daily at bedtime after cleansing.

Formulations

GelCreamLotion

Full Ingredient List

  • Adapalene
  • Carbomer 940
  • Edetate Disodium
  • Methylparaben
  • Poloxamer 182
  • Propylene Glycol
  • Purified Water
  • Sodium Hydroxide

Side Effects

  • Dryness
  • Erythema
  • Scaling
  • Mild burning

Warnings

  • Use sunscreen during treatment
  • Avoid waxing treated areas
  • Discontinue if severe irritation occurs
  • Not for use in pregnancy

Related Conditions

Acne Vulgaris First-line OTC retinoid gel (adapalene 0.1%) Keratosis Pilaris Adapalene gel for stubborn KP (off-label use)