Adapalene

Retinoid (Third Generation)

Also known as: 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid, CD-271

Description

Adapalene is a third-generation synthetic retinoid that selectively binds to RARβ and RARγ receptors. It offers similar efficacy to tretinoin with improved photostability and tolerability. [Thiboutot 2007]

Mechanism of Action

Selectively binds to nuclear retinoic acid receptors RARβ and RARγ, modulating cellular differentiation and keratinization. Inhibits AP-1 factor and toll-like receptor-mediated inflammatory pathways. More photostable and less irritating than tretinoin. [Shalita 1996]

Indications

Available Concentrations

0.1%0.3%

Side Effects

Contraindications

  • Pregnancy [Zaenglein]
  • Eczematous skin at application site
  • Sunburned skin

Pregnancy Category

C [Zaenglein 2016]

Found In

Drugs containing Adapalene

DifferinAdapalene GelEpiduoAdapalene and Benzoyl Peroxide Gel

Cosmetics containing Adapalene

Adaferin Forte Adapalene 0.3% GelGalderma IndiaDeriva CMS Gel (Adapalene 0.1% + Clindamycin 1%)Glenmark

Related Conditions

Acne Vulgaris First-line topical retinoid — comedolytic and anti-inflammatory Keratosis Pilaris Retinoid — reduces follicular plugging

References

  1. Shalita AR, Weiss JS, Chalker DK, et al. "A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris." J Am Acad Dermatol, 1996. doi:10.1016/S0190-9622(96)90753-6
  2. Thiboutot D, Pariser DM, Egan N, et al. "Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial." J Am Acad Dermatol, 2007. doi:10.1016/j.jaad.2006.10.005
  3. Zaenglein AL, Pathy AL, Schlosser BJ, et al. "Guidelines of care for the management of acne vulgaris." J Am Acad Dermatol, 2016. doi:10.1016/j.jaad.2015.12.037

Limitations

This page provides a general overview of Adapalene in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.