Isotroin vs Tretiva
Comparing 2 Drugs
| Property | Isotroin | Tretiva |
|---|---|---|
| Generic Name | Isotretinoin Capsules | Isotretinoin Capsules |
| Manufacturer | Cipla | Intas Pharmaceuticals |
| Type | Prescription | Prescription |
| Category | Oral Retinoid | Oral Retinoid |
| Description | Isotroin is Cipla's branded oral isotretinoin (13-cis-retinoic acid) — the most effective treatment for severe, nodulocystic, and recalcitrant acne. It reduces sebum production by up to 90%, normalises keratinisation, and has anti-inflammatory and anti-bacterial effects. The only acne drug that can induce long-term remission. | Tretiva is Intas Pharma's branded oral isotretinoin — another widely prescribed isotretinoin brand in India. Pharmacologically identical to Isotroin (Cipla). Available in 5mg, 10mg, 20mg, and 40mg strengths for flexible dosing. |
| Active Compounds | Isotretinoin (10mg / 20mg / 40mg) | Isotretinoin (5mg / 10mg / 20mg / 40mg) |
| Indications | Severe nodulocystic acne, Recalcitrant acne unresponsive to conventional therapy, Acne with scarring tendency | Severe nodulocystic acne, Recalcitrant acne, Acne with scarring tendency, Low-dose maintenance for adult acne |
| Dosage | 0.5–1 mg/kg/day for 16–24 weeks. Cumulative dose target: 120–150 mg/kg. Take with fatty food for absorption. | 0.5–1 mg/kg/day for 16–24 weeks. Low-dose (10–20 mg/day) for adult acne maintenance. Take with food. |
| Formulations | Soft gelatin capsule | Soft gelatin capsule |
| Side Effects | Severe dryness (lips, skin, eyes), Elevated liver enzymes and triglycerides, Musculoskeletal pain, Mood changes (monitor carefully), Photosensitivity, Initial acne flare | Cheilitis (dry, cracked lips), Xerosis (dry skin), Elevated triglycerides and LFTs, Musculoskeletal complaints, Dry eyes, Epistaxis |
| Warnings | Pregnancy Category X — ABSOLUTE contraindication (teratogenic), Mandatory pregnancy test before and during treatment, Monthly blood tests (CBC, LFT, lipid panel) required, Avoid blood donation during and 1 month after treatment, Avoid vitamin A supplements, Avoid waxing and laser procedures during treatment | Pregnancy Category X — teratogenic, Monthly blood monitoring mandatory, Two forms of contraception required in women, Avoid concurrent tetracyclines (pseudotumor cerebri risk), Avoid vitamin A supplements |
| Prescription Required | Yes | Yes |
Want a more detailed comparison with ingredient overlap analysis? Open in Compare Tool →