Bakuchiol

Plant-derived Retinoid Alternative

Also known as: Babchi Extract

Description

Bakuchiol is a meroterpene (terpenoid phenol) isolated from the seeds and leaves of Psoralea corylifolia (Babchi). It is functionally similar to retinol, modulating retinol-like gene expression involved in collagen synthesis, cell turnover, and melanogenesis, but does not bind retinoid receptors (RARs/RXRs) and is structurally unrelated to retinoids. Clinical trials have demonstrated comparable anti-aging and anti-pigmentation efficacy to 0.5% retinol, with significantly fewer side effects such as dryness, scaling, and photosensitivity. [Dhaliwal 2019] [Chaudhuri 2014]

Mechanism of Action

Bakuchiol modulates retinol-like gene expression through a retinoid receptor-independent mechanism, upregulating types I, III, and IV collagen gene expression and stimulating collagen synthesis in dermal fibroblasts. It inhibits melanogenesis by suppressing tyrosinase activity and reduces MMP-1 expression, thereby decreasing collagen degradation. Bakuchiol also exhibits antioxidant activity by scavenging free radicals and anti-inflammatory properties by inhibiting NF-κB and COX-2 pathways. Unlike retinoids, it does not increase photosensitivity. [Chaudhuri 2014]

Indications

Available Concentrations

0.5%1%2%

Side Effects

  • Mild irritation (less common than retinol) [Dhaliwal]
  • Rare allergic contact dermatitis [Dhaliwal]
  • Generally well tolerated

Contraindications

  • Known hypersensitivity to bakuchiol or Psoralea corylifolia

Pregnancy Category

Not formally classified (considered safer alternative to retinoids during pregnancy; no teratogenic data reported) [Dhaliwal 2019]

Found In

Cosmetics containing Bakuchiol

Bioderma Sébium Global Intensive Purifying CareBiodermaPlum 1% Retinol Anti-Aging Night Face Serum with BakuchiolPlum

Related Conditions

Acne Vulgaris Anti-comedonal and anti-inflammatory — regulates cell turnover and reduces inflammatory lesions without retinoid-associated irritation Photoaging Anti-aging — stimulates collagen synthesis and reduces MMP-1, comparable to retinol for fine lines and wrinkles Melasma Depigmenting agent — inhibits tyrosinase and modulates melanogenesis-related gene expression

References

  1. Chaudhuri RK, Bojanowski K. "Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects." Int J Cosmet Sci, 2014. doi:10.1111/ics.12117
  2. Dhaliwal S, Rybak I, Ellis SR, et al. "Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing." Br J Dermatol, 2019. doi:10.1111/bjd.17298

Limitations

This page provides a general overview of Bakuchiol in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.