Centella Asiatica Extract

Botanical Anti-inflammatory

Also known as: Cica, Gotu Kola, Madecassoside, Asiaticoside

Description

Centella asiatica is a herbaceous plant used for centuries in Ayurvedic and traditional medicine. Its dermatological activity is attributed to four key triterpenoid saponins: madecassoside, asiaticoside, asiatic acid, and madecassic acid (collectively known as centelloids). These compounds stimulate type I and III collagen synthesis, promote fibroblast proliferation, inhibit inflammatory cytokines, and accelerate wound healing. Centella extract is widely used in Korean skincare ('Cica' products) for calming sensitive, irritated, and acne-prone skin. [Bylka 2014]

Mechanism of Action

Asiaticoside and madecassoside stimulate collagen synthesis by activating the TGF-β/Smad signaling pathway in dermal fibroblasts and upregulating type I procollagen gene expression. Asiatic acid increases antioxidant enzyme activity (SOD, catalase, glutathione peroxidase) and inhibits NF-κB-mediated pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6). Madecassoside promotes angiogenesis and re-epithelialization in wound models. Together, centelloids modulate both the inflammatory and proliferative phases of tissue repair. [Brinkhaus 2000]

Indications

  • Wound healing and scar management [Bylka]
  • Acne and post-acne erythema [Bylka]
  • Sensitive or irritated skin [Brinkhaus]
  • Rosacea-prone skin [Bylka]
  • Photoaging / fine lines [Bylka]
  • Atopic dermatitis adjunct
  • Post-procedural recovery
  • Stretch marks (striae)

Available Concentrations

0.1% (titrated extract — TECA)1%2%5%10%

Side Effects

  • Allergic contact dermatitis (uncommon; sensitization to triterpenoid fraction) [Bylka]
  • Mild irritation in rare cases [Bylka]

Contraindications

  • Known hypersensitivity to Centella asiatica or its triterpenoids [Bylka]
  • History of allergic contact dermatitis to Centella-containing products

Pregnancy Category

Not classified (insufficient data; generally considered safe for topical use at cosmetic concentrations)

Found In

Cosmetics containing Centella Asiatica Extract

Bioderma Photoderm Spot-Age SPF 50+ PA++++BiodermaThe Derma Co Sali-Cinamide Anti-Acne Face SerumThe Derma CoDot & Key CICA Calming Mattifying Sunscreen SPF 50 PA++++Dot & KeyDot & Key 2% Salicylic Acid + Cica Anti Acne SerumDot & KeyFoxtale Essentials Dewy Finish Sunscreen SPF 50 PA++++Foxtale

Related Conditions

Acne Vulgaris Anti-inflammatory — reduces post-acne erythema and supports wound healing of acne lesions Rosacea Anti-inflammatory — calms erythema and strengthens the compromised vascular and epidermal barrier Atopic Dermatitis Barrier support — promotes wound healing and reduces inflammation in eczematous skin Photoaging Collagen stimulator — activates TGF-β pathway to increase type I and III collagen synthesis

References

  1. Brinkhaus B, Lindner M, Schuppan D, et al. "Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica." Phytomedicine, 2000. doi:10.1016/S0944-7113(00)80059-2
  2. Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, et al. "Centella asiatica in dermatology: an overview." Postepy Dermatol Alergol, 2014. doi:10.5114/pdia.2014.40808

Limitations

This page provides a general overview of Centella Asiatica Extract in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.