Kojic Acid

Skin Brightening Agent

Also known as: Kojic Acid Dipalmitate, 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Description

Kojic acid is a natural metabolite produced by several species of fungi (Aspergillus, Penicillium). It chelates copper at the active site of tyrosinase, inhibiting melanin production. Widely used in Indian and Asian depigmenting products, often in combination with arbutin or vitamin C. [Parvez 2006]

Mechanism of Action

Chelates copper ions at the active site of tyrosinase, rendering the enzyme inactive and suppressing melanogenesis. Also exhibits mild antioxidant and antimicrobial properties. Kojic acid dipalmitate is a lipophilic derivative with improved stability. [Lajis 2012]

Indications

Available Concentrations

1%2%4%

Side Effects

  • Contact dermatitis [Parvez]
  • Skin irritation and redness [Parvez]
  • Increased photosensitivity

Contraindications

  • Known hypersensitivity [Parvez]
  • Severely irritated or broken skin

Pregnancy Category

Not classified (consult dermatologist)

Found In

Cosmetics containing Kojic Acid

Asaya 2% Kojic Acid + 1% Alpha Arbutin Face SerumAsayaThe Derma Co 2% Kojic Acid Face Serum with Alpha ArbutinThe Derma CoDr. Sheth's Kesar & 2% Kojic Acid Ampoule SerumDr. Sheth'sFixderma Skarfix-Plus CreamFixdermaFixderma Skarfix-TX Serum with 4% Kojic Acid & 3% Tranexamic AcidFixdermaHyphen Advanced De-Pigmentation Serum with 2% Kojic AcidHyphenKojivit Ultra Gel (Kojic Acid 2% + Arbutin 1%)Micro LabsMelaglow Rich Cream (Tranexamic Acid 3% + Kojic Acid 2%)Mankind Pharma

Related Conditions

Melasma Copper chelation to inhibit tyrosinase Photoaging Depigmenting agent for age spots

References

  1. Lajis AF, Hamid M, Ariff AB. "Depigmenting effect of kojic acid esters in hyperpigmented B16F1 melanoma cells." J Biomed Biotechnol, 2012. doi:10.1155/2012/952452
  2. Parvez S, Kang M, Chung HS, et al. "Survey and mechanism of skin depigmenting and lightening agents." Phytother Res, 2006. doi:10.1002/ptr.1954

Limitations

This page provides a general overview of Kojic Acid in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.