Squalane

Emollient Lipid

Also known as: Hydrogenated Squalene, Plant-Derived Squalane, Olive Squalane, Sugarcane Squalane

Description

Squalane is the hydrogenated (saturated) form of squalene, a naturally occurring lipid produced by human sebaceous glands. Squalene makes up approximately 12% of human sebum. The hydrogenated form, squalane, is more oxidatively stable and is derived from plant sources such as olives, sugarcane, or amaranth. It is a lightweight, non-comedogenic emollient that closely mimics the skin's natural lipids. [Huang 2009]

Mechanism of Action

Squalane integrates into the skin's lipid matrix due to its structural similarity to endogenous squalene. It forms a non-occlusive barrier that reduces transepidermal water loss (TEWL) while maintaining skin breathability. Its excellent spreadability and low viscosity allow rapid absorption without a greasy residue. As an antioxidant precursor, it can quench singlet oxygen radicals. It also enhances the penetration of other active ingredients through the stratum corneum. [Pappas 2009]

Indications

  • Dry skin [Huang]
  • Dehydrated skin [Pappas]
  • Sensitive skin [Huang]
  • Anti-aging (barrier support)
  • Post-procedural care
  • Adjunct to retinoid therapy

Available Concentrations

1%5%10%100% (pure oil)

Side Effects

  • Non-irritating (extremely well tolerated) [Huang]
  • Very rare allergic reaction

Contraindications

  • Known hypersensitivity (extremely rare)

Pregnancy Category

Not classified (generally considered safe)

Found In

Cosmetics containing Squalane

Bioderma Photoderm Spot-Age SPF 50+ PA++++BiodermaBioderma Sensibio Light CreamBiodermaDeconstruct Gel Sunscreen SPF 50 PA++++DeconstructEarth Rhythm Phyto Ceramide Deep Moisture CreamEarth RhythmFoxtale 3% Tranexamic Acid Face Serum with Peptides & NiacinamideFoxtaleMamaearth Skin Illuminate Face Serum with Vitamin C & TurmericMamaearthMinimalist 0.3% Retinol + Q10 Face SerumMinimalistMinimalist SPF 50 PA++++ SunscreenMinimalistPhysiogel AI Calming Relief CreamPhysiogel (LG H&H)Pilgrim 0.5% Retinol + Vitamin C SerumPilgrimPlum 10% Niacinamide Serum with Rice WaterPlumPlum 1% Retinol Anti-Aging Night Face Serum with BakuchiolPlumRe'equil Ceramide & Hyaluronic Acid MoisturiserRe'equil

Related Conditions

Atopic Dermatitis Emollient — mimics skin lipids, restores barrier Contact Dermatitis Emollient — non-irritating lipid replacement Xerosis Emollient — mimics sebaceous lipids

References

  1. Huang ZR, Lin YK, Fang JY. "Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology." Molecules, 2009. doi:10.3390/molecules14010540
  2. Pappas A. "Epidermal surface lipids." Dermatoendocrinol, 2009. doi:10.4161/derm.1.2.7811

Limitations

This page provides a general overview of Squalane in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.