Allantoin

Skin ProtectantCell Proliferant

Also known as: 5-Ureidohydantoin, Glyoxyldiureide

Description

Allantoin is a naturally occurring nitrogenous compound found in botanical extracts (particularly comfrey), animal secretions (snail mucin), and produced synthetically for cosmetic use. It is classified as a skin protectant by the FDA and is widely used for its soothing, anti-irritant, and cell-proliferating properties. [Araújo 2010]

Mechanism of Action

Allantoin promotes cell proliferation by stimulating fibroblast synthesis of extracellular matrix components. It increases the water content of the stratum corneum by enhancing desquamation of dead surface cells, which in turn smooths the skin's texture. It provides anti-irritant effects by forming complexes with irritant substances and sensory irritants. Its keratolytic action at higher concentrations aids in gentle exfoliation without the irritation associated with AHAs or BHAs. [Araújo 2010]

Indications

  • Irritated or sensitized skin [Araújo]
  • Wound healing [Becker]
  • Dry and rough skin texture [Araújo]
  • Post-procedural care [Becker]
  • Anti-aging (cell renewal support)
  • Eczema and psoriasis (adjunct)

Available Concentrations

0.5%1%2%

Side Effects

  • Extremely well tolerated [Becker]
  • Very rare contact allergy

Contraindications

  • Known hypersensitivity (extremely rare)

Pregnancy Category

Not classified (generally considered safe)

Found In

Cosmetics containing Allantoin

Aklief Trifarotene Cream 0.005%GaldermaAqualogica Detan+ Dewy Sunscreen SPF 50+ PA++++AqualogicaAqualogica Illuminate+ Dewy Sunscreen SPF 50+ PA++++AqualogicaBioderma Sensibio Light CreamBiodermaCipla Excela MoisturiserCipla (Rivela Dermascience)Clindac A Gel (Clindamycin 1%)Galderma IndiaThe Derma Co 1% Hyaluronic Sunscreen Aqua Gel SPF 50 PA++++The Derma CoThe Derma Co 1% Hyaluronic Sunscreen Oil-Free Matte Gel SPF 50 PA++++The Derma CoThe Derma Co Pore Minimizing Priming Sunscreen SPF 50 PA+++The Derma CoThe Derma Co Sali-Cinamide Anti-Acne Face SerumThe Derma CoDot & Key Blueberry Hydrate 12% Barrier Boost SerumDot & KeyDot & Key Blueberry Hydrate Barrier Repair Sunscreen SPF 50+ PA++++Dot & KeyDot & Key 10% Glycolic Acid Glow SerumDot & KeyDot & Key 10% Niacinamide + Strawberry Brightening Face SerumDot & KeyDot & Key 2% Salicylic Acid + Cica Anti Acne SerumDot & KeyDot & Key 10% Vitamin C + E Serum with 5% NiacinamideDot & KeyHyphen Brightening Face Serum 5% Niacinamide + 1% Alpha ArbutinHyphenLakme Sun Expert Tinted Sunscreen SPF 50 PA+++LakmeMinimalist Cream Sunscreen SPF 50 PA++++MinimalistMinimalist Sunscreen SPF 60 PA++++MinimalistPilgrim 2% Alpha Arbutin & 3% Vitamin C Brightening Face SerumPilgrimPilgrim 10% Niacinamide Face SerumPilgrimPilgrim 10% Vitamin C Face SerumPilgrimPlum 5% Niacinamide & Rice Water Beginner Friendly Face SerumPlum

Related Conditions

Rosacea Calming and skin-soothing agent Atopic Dermatitis Soothing and barrier-protective agent Contact Dermatitis Skin protectant and soothing agent Xerosis Skin protectant — promotes healing of fissures

References

  1. Araújo LU, Grabe-Guimarães A, Mosqueira VC, et al. "Profile of wound healing process induced by allantoin." Acta Cir Bras, 2010. doi:10.1590/S0102-86502010000500014
  2. Becker LC, Bergfeld WF, Belsito DV, et al. "Final report of the safety assessment of allantoin and its related complexes." Int J Toxicol, 2010. doi:10.1177/1091581810362805

Limitations

This page provides a general overview of Allantoin in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.