Benzoyl Peroxide
Also known as: BPO, Dibenzoyl peroxide
Description
Benzoyl peroxide is a potent bactericidal agent widely used in the treatment of acne vulgaris. It is one of the few topical acne agents to which Cutibacterium acnes does not develop resistance. [Sagransky 2009] [Zaenglein 2016]
Mechanism of Action
Releases free-radical oxygen upon contact with the skin, which oxidizes bacterial proteins in Cutibacterium acnes. Also exhibits mild keratolytic and comedolytic activity. Does not induce bacterial resistance. [Sagransky 2009]
Indications
- Acne vulgaris (inflammatory and comedonal) [Zaenglein]
- Folliculitis [Sagransky]
- Rosacea (adjunctive) [Dutil]
Available Concentrations
Side Effects
- Dryness [Sagransky]
- Erythema [Sagransky]
- Peeling [Dutil]
- Contact dermatitis (rare) [Sagransky]
- Bleaching of hair, clothing, and fabrics
Contraindications
- Known hypersensitivity to benzoyl peroxide [Sagransky]
Pregnancy Category
Found In
Drugs containing Benzoyl Peroxide
Cosmetics containing Benzoyl Peroxide
Related Conditions
References
- Dutil M. "Benzoyl peroxide: enhancing antibiotic efficacy in acne management." Skin Therapy Lett, 2010.
- Sagransky M, Yentzer BA, Feldman SR. "Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris." Expert Opin Pharmacother, 2009. doi:10.1517/14656560903277228
- Zaenglein AL, Pathy AL, Schlosser BJ, et al. "Guidelines of care for the management of acne vulgaris." J Am Acad Dermatol, 2016. doi:10.1016/j.jaad.2015.12.037
Limitations
This page provides a general overview of Benzoyl Peroxide in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.