Neem Extract
Also known as: Melia Azadirachta Leaf Extract, Azadirachta Indica, Indian Lilac
Description
Neem extract is derived from the leaves of the neem tree (Azadirachta indica), a plant native to the Indian subcontinent. It has been used in Ayurvedic medicine for centuries for its antibacterial, antifungal, and anti-inflammatory properties. The active compounds include nimbin, nimbidin, and azadirachtin. [Subapriya 2005]
Mechanism of Action
Contains nimbidin and other limonoids that inhibit bacterial growth (particularly Propionibacterium acnes and Staphylococcus aureus) by disrupting cell membrane integrity. Azadirachtin interferes with prostaglandin synthesis, providing anti-inflammatory effects. Quercetin and other flavonoids contribute antioxidant activity, scavenging free radicals and reducing oxidative stress in the skin. [Subapriya 2005]
Indications
- Acne-prone skin [Subapriya]
- Oily skin [Alzohairy]
- Minor skin infections [Subapriya]
- Inflammatory skin conditions [Alzohairy]
- Dandruff and scalp conditions
Available Concentrations
Side Effects
- Contact dermatitis (rare) [Subapriya]
- Mild stinging on broken skin
- Allergic reaction in sensitive individuals
Contraindications
- Known allergy to neem or Meliaceae family [Subapriya]
- Open wounds (high concentrations)
Pregnancy Category
Not classified (insufficient data; avoid oral use)
Found In
Cosmetics containing Neem Extract
References
- Alzohairy MA. "Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment." Evid Based Complement Alternat Med, 2016. doi:10.1155/2016/7382506
- Subapriya R, Nagini S. "Medicinal properties of neem leaves: a review." Curr Med Chem Anticancer Agents, 2005. doi:10.2174/1568011053174828
Limitations
This page provides a general overview of Neem Extract in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.