Zinc PCA

Mineral Sebum Regulator

Also known as: Zinc Pidolate, Zinc L-Pyrrolidone Carboxylate

Description

Zinc PCA is the zinc salt of pyrrolidone carboxylic acid (PCA), a natural component of the skin's Natural Moisturizing Factor (NMF). It combines the sebum-regulating properties of zinc with the humectant properties of PCA, making it particularly suited for oily and acne-prone skin types. [Gupta 2014]

Mechanism of Action

The zinc ion inhibits 5α-reductase, reducing the conversion of testosterone to dihydrotestosterone (DHT) and thereby decreasing sebum production. Zinc also has intrinsic antimicrobial properties against Propionibacterium acnes by disrupting its lipase activity. The PCA moiety acts as a humectant, attracting and retaining moisture in the stratum corneum without contributing oiliness. Additionally, zinc supports wound healing through its role as a cofactor in metalloproteinases involved in tissue repair. [Piérard-Franchimont 2008]

Indications

Available Concentrations

0.5%1%2%4%

Side Effects

  • Mild dryness (at high concentrations) [Gupta]
  • Skin irritation (rare)

Contraindications

  • Known hypersensitivity to zinc compounds

Pregnancy Category

Not classified (generally considered safe)

Found In

Cosmetics containing Zinc PCA

Cipla Acnelak Z SPF 50 SunscreenCiplaThe Derma Co 1% Hyaluronic Sunscreen Oil-Free Matte Gel SPF 50 PA++++The Derma CoThe Derma Co 10% Niacinamide Face SerumThe Derma CoDot & Key 2% Salicylic Acid + Cica Anti Acne SerumDot & KeyMinimalist 10% Niacinamide Face SerumMinimalistPilgrim 10% Niacinamide Face SerumPilgrimScalpe Pro Anti-Dandruff Shampoo (Zinc Pyrithione 1% + Ketoconazole 2%)GlenmarkThe Ordinary Niacinamide 10% + Zinc 1%The Ordinary (DECIEM)

Related Conditions

Acne Vulgaris Sebum control and mild antimicrobial Seborrheic Dermatitis Antimicrobial and sebum-regulating

References

  1. Capitanio B, Sinagra JL, Wollenberg A, et al. "Underestimated clinical features of postadolescent acne." J Am Acad Dermatol, 2010. doi:10.1016/j.jaad.2009.07.043
  2. Gupta M, Mahajan VK, Mehta KS, et al. "Zinc therapy in dermatology: a review." Dermatol Res Pract, 2014. doi:10.1155/2014/709152
  3. Piérard-Franchimont C, Goffin V, Piérard GE. "A quantitative assessment of the shrinkage of facial skin pores following a single application of zinc active ingredients." J Cosmet Dermatol, 2008.

Limitations

This page provides a general overview of Zinc PCA in dermatology. It does not cover every possible use, formulation, or interaction. Individual responses to compounds vary — what works for one person may not work for another. Always consult a qualified dermatologist before starting or changing any treatment.